منابع مشابه
Paroxetine‐induced QTc prolongation
There have been only two previous reports of paroxetine-induced corrected QT (QTc) prolongation on electrocardiogram (ECG). Here, we report a 43-year-old woman with QTc prolongation (476 ms). She had taken 50 mg of paroxetine for 17 days. Three days after discontinuation of paroxetine, QTc returned to within the normal limits (396 ms). Paroxetine blocks the human ether-a-go-go-related gene (HER...
متن کاملSevoflurane and QTc Prolongation: An Interesting Observation, or a Clinically Significant Finding?
SERIOUS adverse drug reactions are frequently recognized only after postmarketing surveillance has begun. The most common cause of drug restriction or drug withdrawal from the marketplace is prolongation of the QT interval with an associated finding of polymorphic ventricular tachycardia, also known as torsades de pointes (TdP). At least nine structurally unrelated drugs have been removed from ...
متن کاملKetamine-induced QTc interval prolongation
Sir, Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. It is widely used as a dissociative anesthetic and is also used as an adjunct in pain management, particularly in opioid-tolerant patients. It blocks calcium channels and depresses sodium channel function as well as having anticholinergic effects. It inhibits the re-uptake of the catecholamines and may hav...
متن کاملSevoflurane causes greater QTc interval prolongation in chronically hyperglycemic patients than in normoglycemic patients
QTc interval prolongation is a serious diabetic complication and increases mortality rate. Hyperglycemia inhibits the rapid component of delayed rectifier potassium channel currents (Ikr) and prolongs the QTc interval on electrocardiograms. Sevoflurane also inhibits the Ikr and causes QTc interval prolongation. In fact, torsade de pointes occurred in a patient with poorly controlled diabetes me...
متن کاملSevoflurane causes greater QTc interval prolongation in elderly patients than in younger patients.
BACKGROUND Sevoflurane and droperidol prolong the QT interval, and advancing age is not only associated with a prolongation of the QT interval but is also a risk factor for drug-induced QT interval prolongation. In this study, we compared the effect of sevoflurane and droperidol on the corrected QT (QTc) interval and the dispersion of ventricular repolarization (time interval from the peak to t...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2010
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e3181f2b088